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The principal cytochrome P450 isoenzyme concerned seems to be CYP2E1, with CYP1A2 and CYP3A4 as added pathways. Roughly 85% of an oral dose appears while in the urine in just 24 several hours of administration, most because the glucuronide conjugate, with modest amounts of other conjugates and unchanged drug [see OVERDOSAGE] for toxicity data.Long-